The Papua New Guinea University of Technology, or Unitech, is facing a serious staffing threat next year, which may see some departments forced to close.
More than 22 senior staff have resigned from the Lae campus over the past three months, with another three expected.
The National newspaper reports that the staff are leaving because of unresolved differences with the university's management.
It reports that Unitech departments teaching mining, engineering, computer science and chemistry are on the brink of shutting down if replacements are not recruited in time for the new academic year.
The university has a staff ceiling of 180 academic staff members but there are presently only 92.