The Hurricanes pair of Jack Lam and Alapati Leiua will debut for Samoa in the four-nation rugby Test against Scotland in Durban on Sunday.
The pair are among nine changes to the team, beaten 22-14 by France on November's European Tour.
Logovii Ulipola and Olei Avei come into the front row, Daniel Leo returns to the second row while there are five changes in the backline, with Jeremy Su'a, Alesana Tuilagi, Paul Williams and James So'oialo all earning a start.
Williams will captain the team from centre, having played at fullback last weekend in the heavy defeat against the Golden Lions.
Scotland interim head coach Scott Johnson has named three new caps in his side with Edinburgh's Greig Tonks and Glasgow pair Alex Dunbar and Pat MacArthur to make their debuts.