John Brinkley built a multi-million dollar empire during the depression-era America by claiming that goats testicles would cure impotence.
Born in 1885 he claimed to be a medical doctor, but had no formal medical education. He operated clinics and hospitals in several states - where he would implant goats testicles into men to "cure" a range of ailments. His methods were discredited by the medical establishment, but he managed to keep doing his operations for two decades!
But he was also a pioneer in radio, and in spite of his devious money making schemes, actually introduced techniques and standards which became the norm in the industry.
Filmmaker Penny Lane has made the documentary, Nuts about Brinkley after she came across a book about him in her local library.