President Barack Obama's top economics adviser is to leave the administration at the end of the year.
Under Larry Summers, the council has been at the heart of the government's economic policy making.
Mr Obama praised him for "brilliance, experience and judgement" at "a time of great peril" for the United States.
The BBC reports the departure of Mr Summers, who is returning to a post at Harvard University, is the latest from the White House economy team.
Budget director Peter Orszag stepped down in July and Council of Economic Advisers chairwoman Christina Romer left earlier this month.
The White House said Mr Summers had been an architect of the 2009 Recovery act - aimed at jump-starting the US economy - and also, among other roles, led an overhaul of the automobile industry.