Nine people were injured on State Highway 1 north of Dunedin after a van struck a herd of cattle.
The incident happened at Waikouaiti just after midnight on Saturday.
An ambulance spokesman says one person was flown by rescue helicopter to Dunedin with a serious head injury, another suffered a broken femur, while the other seven received minor injuries.
All were taken to Dunedin Hospital for treatment.
In another incident; a man, 27, is in Dunedin Hospital after falling from the second story of a building in the central city.
An ambulance spokesman says the man suffered critical injuries.