The Government has again moved to ban ingredients found in tested samples of the legal high known as K2.
In November last year, Associate Health Minister Peter Dunne banned a substance found in two K2 products.
Since then manufacturers have replaced the ingredients, but two of those have now also been outlawed.
Mr Dunne said on Tuesday the move will be another blow to the legal high industry and effectively means K2 products must be removed from shop shelves by 9 May.
Legislation will be in place by August this year requiring legal high manufacturers to prove that their products are safe before they can be sold.