Relegation-threatened Wigan has shocked English football giants Liverpool 2-1 at Anfield, while Manchester City are back on top of the Premier League - for now - after a 1-1 draw at Stoke City.
Gary Caldwell's second-half winner allowed struggling Wigan Athletic to record their first ever victory at the famous Liverpool ground as the hosts surely saw their lingering hopes of a top-four finish disappear.
Manchester City went behind at Stoke to a wondrous Peter Stoke goal after half-time but Yaya Toure's deflected equaliser meant the visitors went home top of the league on goal difference from second-placed Manchester United, who host Fulham on Tuesday.
Arsenal increased their advantage in the race for Champions League football after a deserved 3-0 Premier League home win over Aston Villa at the Emirates in London, the seventh win in a row for Arsene Wenger's men.
But more significantly, the Premier League's form side stretched their lead over nearest rivals Tottenham, who are in fourth place, to three points and eight points over fifth-placed Chelsea.
Chelsea missed the chance to close the gap on Spurs in the race for a top-four finish, drawing 0-0 in the early kick-off at Stamford Bridge in London.
Bolton climbed out of the relegation zone above Queen's Park Rangers with a 2-1 victory in an emotional relegation home derby victory over Blackburn that became a moving tribute to stricken Wanderers player Fabrice Muamba.
Londoners QPR lost 3-1 at Sunderland while Norwich beat struggling visitors Wolves 2-1, and Swansea lost 2-0 at home to Everton.