Ricky Stuart's State of Origin plans have been thrown into disarray, with New South Wales certainties Kurt Gidley, Danny Buderus, Michael Jennings and Luke Lewis all suffering injuries as Newcastle beat Penrith 34-14 last night.
Gidley picked up the most serious of them - a recurrence of his left shoulder injury suffered against Cronulla earlier this season - when he attempted a tackle.
Buderus's night ended in the first half with a flare up of the Achilles injury which kept him out of City-Country last weekend, while Jennings left the field with 20 minutes to go with a shoulder injury.
Jennings suffered nerve damage to his neck after landing awkwardly while attempting to score a try, and was soon joined in the Penrith injury ward when Lewis left the field favouring his left arm which had hampered him throughout the second half.
The Knights, spurred on by a pumped up Willie Mason in his first National Rugby League match since 2010, put in their most polished attacking performance of the year and dominated the contest with their left-hand attack of Timana Tahu and James McManus causing headaches all night.