Young halfback Maxime Machenaud will start for France against Australia at the Stade de France on Saturday with the more experienced Morgan Parra on the bench.
The 23-year-old Machenaud earned his first and only cap when France crushed Argentina 49-10 in June.
France also named novice prop Yannick Forestier in one of five changes from the team who played Argentina when Saint-Andre rested several experienced players.
Machenaud will link up with flyhalf Frederic Michalak who started by his side in Argentina on his return to the France team after two years' absence.
Scrumhalf Parra, who has 43 caps, was called into the squad though he is still recovering from a thigh injury.
Toulouse flanker Yannick Nyanga, who has not featured for France since the 2007 World Cup, replaces Alexandre Lapandry, who was not named in the preliminary squad.
Saint-Andre also picked Forestier rather than Thomas Domingo who has 18 caps. Prop Nicolas Mas returns after he was rested during the Argentina's tour.
Toulouse winger Vincent Clerc, France's most effective try scorer, is also back in the team instead of Yoann Huget.