Goals from Ryan Giggs and Park Ji-sung gave Manchester United a clinical 2-0 win at Middlesbrough on Saturday to extend their lead in the Premier League to six points with four games remaining.
United were without the injured Rio Ferdinand and rested Cristiano Ronaldo, Edwin van der Sar and Michael Carrick in advance of Tuesday's Champions League semi-final, second leg at Arsenal where they hold a 1-0 lead.
Chelsea are behind Liverpool on goal difference after Nicolas Anelka and Didier Drogba were on target in a 3-1 home defeat of west London rivals Fulham although they have just three games left. Arsenal are fourth with 68 points following a 3-0 victory at Portsmouth.
Defeat left Boro second from bottom with 31 points with only three games remaining. Newcastle are above them on goal difference while Hull, who go to Aston Villa on Monday, have 34.
Bottom side West Bromwich Albion appear doomed on 28 points after losing 1-0 at Tottenham Hotspur while Blackburn Rovers still have relegation concerns after a 3-1 defeat at Manchester City.
West Ham United won 1-0 at Stoke City to go seventh while Wigan Athletic and Bolton Wanderers drew 0-0.