Some 500 doping samples from the Beijing Olympics will be re-tested in January.
About 400 blood tests searching for the illegal use of CERA, a new version of the endurance-enhancing hormone EPO, will be conducted at World Anti-Doping Agency-accredited laboratories in Paris and Lausanne.
A further 100 urine samples will be checked for insulin at a WADA lab in Cologne, Germany.
The lab recently perfected a test for the hormone, which can serve as an anabolic agent to enhance an athlete's performance.
The IOC says the tests "will primarily target endurance events in cycling, rowing, swimming and athletics".
The IOC says it conducted 4,770 doping tests during the Beijing Olympics, including nearly 1,000 blood screenings.