World football champions Spain suffered their worst defeat for 47 years as Portugal hammered their neighbours 4-0 in a Lisbon friendly arranged to promote the countries' joint World Cup bid.
In another big derby, played in neutral Qatar, Argentina beat Brazil 1-0 courtesy of a stoppage-time Lionel Messi special.
Amoung the other 40 matches worldwide, there were a clutch of impressive away wins in Europe as France beat England 2-1 at Wembley, Belgium upset Russia 2-nil, Norway overcame Ireland 2-1 and Greece defeated Austria 2-1.
World Cup runners-up Netherlands beat Turkey 1-nil but several of Europe's other big guns failed to ignite.
Germany were held to a goalless draw in Sweden, Italy, with four debutants, drew 1-all with Romania in Austria in a game marred by racist chanting from Italian fans, while Denmark against Czech Republic also ended nil-all.
In today's two Euro 2012 qualifiers, Croatia beat Malta 3-nil and Finland thrashed San Marino 8-nil.