Manchester United inflicted more Champions League misery on Chelsea as Javier Hernandez and Park Ji-sung scored on either side of half time at Old Trafford to secure a 2-1 victory to fire them into the semi-finals 3-1 on aggregate.
Didier Drogba had put Chlesea level in the second half despite having Ramires sent off for a second yellow card.
United, who beat Chelsea on penalties in the 2008 final, absorbed plenty of pressure and manager Alex Ferguson says they deserved the win and praised the veteran Ryan Giggs for setting up both goals.
The Chelsea manager Carlo Ancelotti, who will come under pressure after his side's last realistic chance of silverware vanished, had no complaints.
Meanwhile Barcelona set up a probable semi-final clash with Spanish rivals Real Madrid after Lionel Messi netted in a 1-nil win at Shakhtar Donetsk to complete a 6-1 aggregate success.