South Africa's team for Saturday's Tri-Nations opener against Australia has been further weakened by the withdrawal of lock Johann Muller with a hamstring injury.
The 23-Test forward will be replaced by Alistair Hargreaves, who has two caps.
Ryan Kankowski replaces Hargreaves on the bench.
The Springboks left 21 frontline players back in South Africa because of injury and will give debuts to three players with another uncapped player on the bench.
