Seamer Zaheer Khan needs surgery for ankle and hamstring problems and has been ruled out of the remainder of India's cricket tour of England.
Left-arm paceman Rudra Pratap Singh will replace Zaheer for the remaining two tests, a Twenty20 and five one-day internationals.
The 32-year-old Zaheer could need up to four months to fully recover.
The left-arm paceman, who missed India's full tour of West Indies due to the ankle problem, had to leave the field on the first day of the series at Lord's and subsequently missed the second test at Trent Bridge.
Replacement RP Singh has not played for India in any form of cricket since September 2009, with his last test match being against South Africa in April 2008.
