Ten-man Real Madrid slumped to a surprise 1-0 defeat at Levante as the tiny Valencia-based football club ended the nine-times European champions' perfect start to the season.
Jose Mourinho's side had midfielder Sami Khedira sent off five minutes before half-time and fell behind when Levante forward Kone, who joined from Sevilla in the close season, smashed the ball into the net with just over 20 minutes left.
The result leaves Real on six points from three matches, one behind champions Barcelona, who romped to an 8-0 victory at Osasuna with a devastating performance after a poor week by their high standards.
Valencia, who beat Sporting Gijon 1-0 away on Saturday, are top on a perfect nine points and ahead of promoted Real Betis on goal difference after the Seville-based outfit beat Marcelo Bielsa's Athletic Bilbao 3-2 in the late kickoff.
In the earlier kickoff, Atletico Madrid's new signing Radamel Falcao lit up the Calderon with a splendid hat-trick to set Gregorio Manzano's side on their way to a 4-0 win at home to Racing Santander.
Real Zaragoza forward Luis Garcia had an eventful match against his former club Espanyol, smashing in a stoppage-time winner for a 2-1 victory minutes after he seeing his penalty saved by Cristian Alvarez.
In the Madrid derby, promoted Rayo Vallecano claimed their first win of the campaign with a 1-0 success at Getafe.