Captain John Smit will be rested for South Africa's final Rugby World Cup group match against Samoa and lock Bakkies Botha could join him on the sidelines after suffering another injury.
The Springboks lead Pool D after victories over Wales, Fiji and Namibia and are heavy favourites to win the group at the North Harbour Stadium in Albany on Friday.
Botha injured his Achilles before the World Cup and missed the opening 17-16 victory over Wales, returned for the 49-3 win over Fiji, but hobbled from the field as the Springboks thrashed Namibia 87-0 in Albany last Thursday.
Coach Peter de Villiers says Botha is a worry and isn't where he wants him to be.
Botha is not the only injury concern for the twice champions with second row Victor Matfield (hamstring) and centre Jean De Villiers (sore ribs) also causing headaches.