Yaya Toure struck twice for Manchester City as the Champions League debutants thumped injury-ravaged Villarreal 3-0 away to boost their chances of qualifying for the last 16.
Antonio Valencia's early goal set Manchester United on their way to an unconvincing 2-0 victory over Otelul Galati.
Real Madrid sealed their place in the knockout phase after Cristiano Ronaldo scored in each half to give the Spanish Giants a 2-nil win over Lyon.
Inter Milan enjoyed a 2-1 win over Lille, their third in a row as last 16 qualification edged closer.
In other results Bayern Munich had a 3-2 win over Napoli, Basel managed a 1-1 draw at Benfica, and the Dutch side Ajax Amsterdam enjoyed a 4-0 home win over Dinamo Zagreb.