Senior Pakistani militant leader Mullah Nazir has been killed by a US drone strike in Pakistan, local security officials say.
He was killed along with at least five fighters when two missiles struck in the north-western tribal district of South Waziristan, the BBC reports.
He had been accused of sending fighters to support the Afghan Taliban and fight foreign and pro-government troops.
Nazir was wounded in a suicide bomb attack in November.
It is not clear whether Wednesday night's drone strike targeted a house or a car in Angoor Adda, near South Waziristan's main town of Wana, close to the Afghan border.
Reports say Nazir's deputy, Ratta Khan, was also killed in the attack.
Officials also said four militants were killed in a separate attack in North Waziristan, but their identities are not known.
Local residents were quoted as saying that they heard on mosque loudspeakers announcements that Mullah Nazir was dead and that a funeral service for him would be held on Thursday.
Analysts say Mullah Nazir had formed an alliance with the government and opposed the Pakistani Taliban, with whom he was at odds because he favoured attacking US forces in Afghanistan rather than Pakistani soldiers.
His death could be a contentious issue between Washington and Islamabad, they add, because the Pakistani military views commanders like him as key to keeping the peace internally.
His group is one of several Taliban factions operating in Pakistan's restive north-west - in recent years there have been divisions among these groups.
Drone strikes have increased in frequency since US President Barack Obama took office in 2009. Hundreds of people have been killed, stoking public anger in Pakistan.
The dead include senior al-Qaeda and Taliban leaders, as well as an unknown number of other militants and civilians.
The US does not normally comment on individual drone operations, but last year it emerged in the New York Times that the US president personally approved or vetoed each drone strike.
Islamabad has called for an end to the attacks saying they violate the country's sovereignty, but analysts say Pakistan has privately sanctioned such actions in the past.