Hillary Clinton won Senate approval as US Secretary of State on Wednesday.
The Senate easily approved her nomination by President Barack Obama. She replaces former Secretary of State Condoleezza Rice.
The final Senate vote was 94 to 2.
During debate, Republican Senator John Cornyn, of Texas, raised the issue of possible conflicts of interest created by foreign donations to the charitable foundation of Mrs Clinton's husband, former President Bill Clinton.
But Mr Cornyn and other Republicans said they still supported Mrs Clinton's nomination, believing it is crucial that she be allowed to get to work.
Senators from the Democrat and Republican parties, including John McCain of Arizona, praised Mrs Clinton as uniquely qualified to be Secretary of State.