The injury-hit Wallabies have made five changes to the side well beaten by the Springboks for their last Rugby Championship match against Argentina in Rosario this weekend.
Western Force winger Nick Cummins will become the 11th new cap, and the 38th player to represent Australia this year.
Following injuries to Berrick Barnes and Adam Ashley-Cooper last weekend there is a reshaped backline with New Zealander Mike Harris starting at fullback and Ben Tapuai in the centres.
In the forwards, Sitaleki Timani starts at six and James Slipper at prop.
The weekend's starting XV totals a combined 345 previous Test appearances - 110 of which belong to Nathan Sharpe, the Australian captain.
In playing his 111th Test, Sharpe moves into outright second for the most Test matches played by an Australian, while also edging ahead of the 110-matches played by flanker George Smith, to become the most capped Australian Test forward in history.
Argentina have named an unchanged lineup.
