Argentina have made five changes from the team beaten 54-17 by Australia in the Rugby Championship last month for their opening tour match against England at Twickenham this weekend.
New coach Daniel Hourcade has named a side with three changes in the backs and two in the forwards plus a positional switch with Julio Farias Cabello moving from lock to openside flanker.
Juan Manuel Leguizamon will lead the side from his regular number eight position with youngster Pablo Matera moving from openside to blindside flanker to stand in for injured Rugby Championship captain Juan Fernandez Lobbe.
Maximiliano Bustos comes into the front row for injured prop Juan Figallo while a last-minute change in the match squad means Eusebio Guinazu retains his place in the team as hooker because Agustin Creevy withdrew due to injury.
Lucas Gonzalez Amorosino comes into the team at fullback in place of the injured Juan Martin Hernandez and Santiago Fernandez at inside centre for Felipe Contepomi.
Tomas Cubelli has been preferred to Martin Landajo at halfback in a switch between two players who play their club rugby in the amateur Buenos Aires club championship.
England, who beat Australia 20-13 last weekend, won a two-test series 2-0 in Argentina in June.
The Pumas have beaten England once at Twickenham, in 2006.
Argentina continue their tour against Wales and then Italy.