Four-time Australian Open champion Roger Federer faces a giant challenge from revenge-bent Frenchman Jo-Wilfried Tsonga in the fourth round.
Tsonga, the powerful and charismatic 2008 runner-up, lost a five-set quarter-final to Federer at last year's tournament.
Before that match, world number one Rafael Nadal will face Japanese 16th seed Kei Nishikori.
Fourth-seeded Scot Andy Murray meets French lucky loser Stephane Robert and Bulgarian
Grigor Dimitrov faces Spain's unseeded Roberto Bautista Agut in Monday's other men's matches.
In the women's draw, defending champion Victoria Azarenka will meet Sloane Stephens for the first time since beating the American in last year's semi-finals.
Third seed Maria Sharapova plays Dominika Cibulkova, fifth seed Agnieszka Radwanska takes on unseeded Spaniard Garbine Muguruza and Jelena Jankovic faces Simona Halep.