Shane Watson has been ruled out of the first cricket Test against South Africa.
Watson has been suffering from calf tightness this week, and team management decided on Saturday he would not be ready to take on the Proteas on Wednesday.
Alex Doolan is expected to debut at No.3 in the batting order in place of Watson in Centurion.
Watson is a chance of returning for the second Test in Port Elizabeth starting on February 19.
Australia have already lost all-rounder James Faulkner and batsman Shaun Marsh from the original squad selected for the tour, which includes three tests and three Twenty20 internationals.