Barcelona star Neymar has been ruled out for up to a month with a foot injury, compounding a nightmare eight days for the Spanish football champions.
Defender Jordi Alba has also been ruled out for up to a month with a thigh muscle injury.
The injuries were sustained during Thursday's King's Cup final defeat to Real Madrid, with Neymar sidelined for about four weeks and Alba for three to four weeks, leaving them in a race to regain fitness before the end of the season.
They should return for Barca's final La Liga match at home to current league leaders Atletico Madrid on May 19th.
The Catalan side's 2-1 defeat by Real in the King's Cup showpiece followed their Champions League exit at the hands of Atletico a week earlier and a shock 1-0 La Liga defeat at Granada last weekend.
With five games left, Barca are third in the standings, four points behind Atletico and one behind second-placed Real.