Manchester United midfielder Paul Pogba could face his brother Florentin after Jose Mourinho's side were drawn against St Etienne in the Europa League round of 32, a tie which will also stir memories of the dark days of hooliganism in the 1970s.
The sides met in the old European Cup Winners' Cup in 1977-78 but the first leg in St Etienne was marred by violence involving United supporters.
The English side were kicked out of the competition by UEFA but reinstated on appeal and ordered to play their home leg outside Manchester, choosing to stage the game in Plymouth in southwest England.
They won 2-0 to go through 3-1 on aggregate.
Florentin Pogba, a Guinean international, is a defender for St Etienne although he has only been picked intermittently this season. His brother Paul, who plays for France, joined United from Juventus in the close season for a world record fee.
Borussia Moenchengladbach and Fiorentina, two of the most familiar names in European club football, will meet for the first time.
AS Roma, the only other Serie A team left in the competition after Inter Milan and Sassuolo failed to get past the group stage, are involved in another high- profile match against Spain's Villarreal.
Israel's Hapoel Beer Sheva, who beat Inter during the group stage, were rewarded with a tie against Besiktas, one of eight teams parachuting in from the Champions League.
Two of the other top ties pitted AZ Alkmaar against Olympique Lyonnais and PAOK against Schalke, a repeat of their Champions League playoff tie in 2013-14 which the Bundesliga side edged 4-3 on aggregate.
Europa League last-32 draw:
Athletic Bilbao v APOEL Nicosia, Legia Warsaw v Ajax Amsterdam, Anderlecht v Zenit St Petersburg, Astra v Genk, Manchester United v St Etienne, Villarreal v AS Roma, Ludogorets v Copenhagen, Celta Vigo v Shakhtar, Donetsk, Olympiakos v Osmanlispor, Gent v Tottenham Hotspur, Rostov v Sparta Prague, Krasnodar v Fenerbahce, Borussia Moenchengladbach v Fiorentina, AZ Alkmaar v Olympique Lyonnais, Hapoel Beer Sheva v Besiktas, PAOK Salonika v Schalke 04.