Two goals from Marcos Alonso gave Chelsea a 2-1 victory over Tottenham Hotspur in the first-ever Premier League game at Wembley Stadium.
Meanwhile Newcastle fell to a 1-0 defeat at Huddersfield Town in a meeting of two promoted clubs.
For all the noise and wall of flags that greeted Tottenham's arrival at Wembley Stadium, Spurs needed an early goal to feel at ease in their new surroundings.
It was Chelsea, though, who made the breakthrough against the run of play on 23 minutes when Alonso thumped home a superb free kick from 20 metres after Dele Alli had fouled David Luiz.
The shock jolted Spurs who spent much of the game peppering Chelsea's goal, with Harry Kane hitting the post and Christian Eriksen also going close.
They eventually got a goal on 82 minutes but only when Michy Batshuayi headed an Eriksen free kick into his own goal two minutes after coming on as a substitute.
The striker looked disconsolate but the goal heralded a frantic finale in which Tottenham had a penalty appeal turned down and Chelsea scored on the counter-attack after 88 minutes when Luiz intercepted and Pedro fed Alonso on the overlap.
The fullback shot low but must have been as surprised as anyone when goalkeeper Hugo Lloris somehow let the ball through.
"We played a very good game," said Alonso. "I don't think I ever hit a better free kick than the first, not even in training."
Midfielder Luiz was at the heart of most that was good about Chelsea, breaking down Tottenham attacks and pushing his team forward. Asked what instructions he had received from manager Antonio Conte, Luiz said: "Run."
He added: "He told me to cut out the space to create. We were clever and played a very good game."
It was Chelsea's fourth successive win over Spurs at the national stadium -- the previous three were in cup games -- and hardly bodes well for Tottenham's temporary home while their new stadium is being built. In their past 11 games at Wembley, Spurs have won only twice.
Huddersfield Town have a 100 percent record in their first season in the top flight in 45 years after they followed up last week's 3-0 triumph at Crystal Palace with a 1-0 win over Newcastle United on Sunday.
Roared on by a 24,128 crowd, Huddersfield attacked from the outset and then defended with determination after they went ahead through Aaron Mooy.
Mooy's stunning strike came in the 50th minute when he played a neat one-two at the top of the box with striker Elias Kachunga, before the Australian curled his effort past Newcastle keeper Rob Elliot into the top right corner.
The lead up to the goal featured 26 straight passes from Huddersfield, the most from any EPL team in a goalscoring sequence this season.
The goal also earned Mooy a slice of history as it is the first Premier League goal to be scored by the Terriers at The John Smith's Stadium.
"I don't have to pinch myself but I didn't expect it," said manager David Wagner after the club's opening home game.