The Syrian government denies that its forces have used chemical weapons against opposition groups.
The United States and Britain have pointed to emerging evidence that Syria has used weapons such as the nerve gas sarin, the BBC reports.
However the country's information minister, Omran al-Zoubi, says the Western accusations have no credibility, and repeated the government's line that it would never use such weapons on moral and humanitarian grounds.
Mr al-Zoubi also expressed Syria's distrust of US and British membership of a United Nations team waiting to enter the country to gather evidence.
On Friday, US president Barack Obama said if chemical weapons were proved to have been used it would be a game-changer.