Angelina Jolie is to receive the Jean Hersholt Humanitarian Award from the Academy of Motion Picture Arts and Sciences in November.
Veteran actress Angela Lansbury, comedian Steve Martin and costume designer Piero Tosi will also be honoured.
A long-serving goodwill ambassador for the United Nations, Jolie became a special envoy for the organisation in 2012.
The BBC reports the role has taken her to refugee camps in more than 30 countries, including Sierra Leone, Darfur, Iraq, Afghanistan and Libya.
Jolie won an Oscar in 2000 for Girl, Interrupted and was also nominated in 2009 for The Changeling.
Lansbury, 87, received three Oscar nominations over the course of her career, for her work in Gaslight, The Picture of Dorian Gray and 1962's The Manchurian Candidate.
A gifted stage actress, she also has five Tonys and was a household name in Murder, She Wrote?, a long-running TV series .
Martin is best known for his early hits such as The Jerk (1979) and Planes, Trains & Automobiles.
Tosi, 86, is best known in his field for his work on Luchino Visconti's films The Leopard, Death in Venice and Ludwig.