Pope Francis has begun his tour of the United States, where he is expected to greet millions of American Catholics and address thorny issues like climate change and income inequality.
US President Barack Obama welcomed the pope as he landed on Tuesday - a rare honour for a foreign dignitary.
The pontiff will visit Washington DC, New York and Philadelphia.
Before he departed Cuba on Tuesday, he called on its people to live a "revolution of tenderness".
In the final Mass of his four day visit to the island, with President Raul Castro attending, he urged thousands of Cubans to serve one another and not an ideology.
On the trip from Cuba to the US, Pope Francis held a news conference and answered those who said his criticisms of capitalism went too far.
"I've never said anything that is not in the social doctrine of the church," the pope told reporters.
"Maybe I have given the impression of (being) a bit lefty, but that would be a mistaken interpretation."
When he landed at Andrews Air Force Base, the pope was greeted by Mr Obama and his family along with Vice-President Joe Biden and his wife.
The crowd, which included a military honour guard, school children, politicians, and Roman Catholic clergymen, chanted: "Welcome to the USA! Hello! Hey!"
After a brief chat with Mr Obama, the pope rode away in a small charcoal-gray Fiat as part of a motorcade bound for the Vatican diplomatic mission in Washington.
This will be Pope Francis' first visit to the US.
Taking questions from journalists, the Pope answered in Spanish and Italian for almost half an hour - apologising that English was not his forte.
Asked why he had not met dissidents in Cuba, he said he had had no private audiences with anyone. However, he had greeted all those invited to meet him on the steps of Havana Cathedral - who may have included dissidents.
Now, Pope Francis was starting to focus on the US leg of his visit - which could be just as tricky a diplomatic balancing act.
Authorities have launched one of the biggest security operations in US history to ensure the pope's safety.
The pontiff, who has sought to bring Catholics back to the church with a more inclusive message, is very popular in the US and is expected to draw massive crowds in all three cities.
A large portion of central Philadelphia will be practically closed off during his visit and federal employees in Washington have been urged to work remotely while the pope is in the capital.
The event could attract up to 1.5 million people.