UN Secretary-General Ban Ki-moon has voiced alarm "over reports of atrocities against a large number of civilians" in Syria's city of Aleppo.
Mr Ban urged all the sides, particularly Syria's government and its allies, to protect civilians.
UN humanitarian adviser Jan Egeland earlier said Syria and Russia were "accountable" for any atrocities committed by pro-government militias.
Major gains by Syria's army have left Aleppo rebels on the brink of defeat.
In a statement, Mr Ban's spokesman Stephane Dujarric said "the secretary-general is alarmed over reports of atrocities against a large number of civilians, including women and children, in recent hours in Aleppo".
"While stressing that the United Nations is not able to independently verify these reports, the secretary-general is conveying his grave concern to the relevant parties.
"He has instructed his special envoy for Syria to follow up urgently with the parties concerned," the statement added.
So far there have been no public comments on the issue by Syria's government or its ally Russia.
Mr Egeland earlier tweeted that the governments of Syria and Russia were "accountable for any and all atrocities that the victorious militias in Aleppo are now committing".
Rebels have now lost more than 90 percent of the territory they once held in eastern Aleppo, since government forces stepped up their offensive to regain full control of the city a month ago.
Earlier on Monday, Lt Gen Zaid al-Saleh, head of the Syrian government's local security committee, said rebel fighters did not "have much time" and needed to "surrender or die".
Tens of thousands of civilians are also believed to be in the rebel enclave.
Syrian state TV showed footage of people in Aleppo celebrating, amid reports the army was close to victory.
For much of the past four years the city has been divided roughly in two, with the government controlling the western half and rebels the east.
Syrian troops finally broke the deadlock with the help of Iranian-backed militias and Russian air strikes, reinstating a siege on the east in early September and launching an all-out assault weeks later.
Russia, which backs Syrian President Bashar al-Assad, says more than 100,000 civilians have been displaced by the fighting and that 2200 rebel fighters have surrendered.
The Syrian Observatory says that at least 415 civilians and 364 rebel fighters have been killed in rebel-held areas since 15 November. Another 130 civilians have died in rebel rocket and mortar attacks on the government-controlled west.
Russia and the United States, which backs the rebels, held talks in Geneva over the weekend to discuss a deal for civilians and rebel fighters to leave Aleppo.
But on Monday, US officials said their Russian counterparts had rejected a proposal for an immediate cessation of hostilities to allow for safe departures.
Analysts say the fall of Aleppo would be a big blow to the opposition, as it would leave the government in control of Syria's four largest cities.