The Russian military may have killed the leader of Islamic State with an air strike on Raqqa in late May, and is checking the information, it has reported.
The air strike was launched after Russian forces in Syria received intelligence that a meeting of Islamic State leaders was being planned, the ministry said in a statement posted on its Facebook page.
"On May 28, after drones were used to confirm the information on the place and time of the meeting of IS leaders, between 12.35am and 12.45am, Russian air forces launched a strike on the command point where the leaders were located," the statement said.
"According to the information which is now being checked via various channels, also present at the meeting was Islamic State leader Abu Bakr al-Baghdadi, who was eliminated as a result of the strike," the ministry said.
The US-led coalition fighting Islamic State said it could not confirm the Russian report that Baghdadi may have been killed.
The strike was believed to have killed several other senior leaders of the group, as well as about 30 field commanders and up to 300 of their personal guards, the Russian defence ministry said.
The IS leaders had gathered in a southern suburb of Raqqa to discuss possible routes for the militants' retreat from the city, the statement said.
The US was informed in advance about the place and time of the strike, the Russian military said.
Islamic State fighters are close to defeat in the twin capitals of the group's territory, Mosul in Iraq and Raqqa in Syria.
Russian forces support the Syrian government, which is fighting against Islamic State mainly from the west, while a US-led coalition supports Iraqi government forces fighting Islamic State from the east.
The last public video footage of Baghdadi shows him dressed in black clerical robes declaring his caliphate from the pulpit of Mosul's medieval Grand al-Nuri mosque in 2014.
Born Ibrahim al-Samarrai, Baghdadi is a 46-year-old Iraqi who broke away from al Qaeda in 2013, two years after the capture and killing of the group's leader Osama bin Laden.
Rami Abdulrahman, director of the Syrian Observatory for Human Rights, cast doubt on the report Baghdadi may have been killed. He said that according to his information, Baghdadi was located in another part of Syria at the end of May.
"The information is that as of the end of last month Baghdadi was in Deir al-Zor, in the area between Deir al-Zor and Iraq, in Syrian territory," he said by phone.
He questioned what Baghdadi would have been doing in that location.
"Is it reasonable that Baghdadi would put himself between a rock and a hard place of the [US-led] coalition and Russia?"