South Africa routed Australia 53-8 in Tri-Nations rugby in Johannesburg, on Saturday.
It is the Wallabies' worst Test loss in the republic.
Winger Jongi Nokwe scored four tries. Others were scored by lock Andries Bekker, centre Adrian Jacobs, replacement flyhalf Ruan Pienaar and Odwa Ndungane.
Replacement fullback Percy Montgomery added two conversions and flyhalf Butch James kicked three conversions and a penalty.
The Wallabies managed one try by fullback Drew Mitchell. Flyhalf Matt Giteau added a penalty.
South Africa led 27-3 at half-time.
Australia coach Robbie Deans said afterwards: "It was a great win, a good performance by the Springboks."
However, South Africa ended the series in third place with 10 points. Australia are second with 13 points, one point behind New Zealand.
The Wallabies meet the All Blacks in Brisbane on 13 September for the final Test of the series.
After the match, South African fullback Percy Montgomery announced his retirement from international rugby. Saturday's victory over Australia was his 102nd cap.
Montgomery scored 893 points in an 11-year career that spanned South Africa's successful Tri-Nations championships in 1998 and 2004, as well as winning the World Cup in France last year.
He will continue to play for Western Province in the Currie Cup this year and is also available for the Stormers next season.