A school in Cairns is the first in Queensland to be closed due to the swine flu outbreak.
Queensland Health Minister Paul Lucas says a girl, 13, from St Monica's College tested positive to the virus on Saturday night, bringing the total number of cases in Queensland to 15.
There are 303 cases throughout Australia, mostly in Victoria.
The ABC reports the school will be closed for seven days.
Ten schools are closed in Victoria due to the swine flu outbreak. although Health Minister Nicola Roxon says a number of those will reopen early next week.
Every state and territory of Australia is now dealing with cases, with the Northern Territory recording its first case.
Earlier, passengers aboard a P&O cruise ship disembarked in Brisbane on Saturday after being screened for swine flu.
Only 83 of the 2000 passengers aboard the Pacific Dawn, were allowed to leave the ship after it berthed, but they have to spend seven days in home quarantine.
Others will be allowed off the ship when it reaches Sydney on Monday.