The Spanish duo Barcelona and Atletico Madrid have reached the Champions League last 16 with two games remaining in the group stage.
Barcelona reached the knockout stage for the 10th consecutive season with a 3-1 win over struggling Italian giants AC Milan.
For Atletico, their 4-0 win over Austria Vienna earned them their first appearance in the knockout stage since the 2008/09 season.
They also registered a new club record for successive wins in Europe's elite competition with four, beating the previous mark set by their predecessors in the 1958/59 campaign.
Holders Bayern Munich and Manchester City had qualified for the last 16 on Tuesday.
Meanwhile, Aaron Ramsey scored in the second half with Arsenal's first attempt on goal for a 1-0 victory at Borussia Dortmund.
In London, Samuel Eto'o scored for his fourth different Champions League club as Chelsea beat Schalke 3-0 to close in on the knockout phase.