Air New Zealand is cutting services between Hong Kong to London from March 2013 as the airline focuses on returning its international network to profitability.
Seventy cabin crew jobs based in London will be cut.
The company says a review of the service has confirmed the route will not make money in the foreseeable future.
In a separate move, the airline has also formed a strategic agreement with Cathay Pacific on the Auckland to Hong Kong route.
Shares in Air NZ rose 2 cents to $1.22 each on Tuesday.